p-Ethynylphenylalanine

Research use only, not for human use.

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a selective, effective, and reversible tryptophan hydroxylase (TPH) inhibitor, exhibits competitive inhibition with a Ki of 32.6 μM.

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Animal Model:Male Sprague-Dawley rats (200 g) Dosage:30 mg/kg Administration:Intraperitoneal injection Result:Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

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Immunology/Inflammation

Hydroxylase

Hydroxylase

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278605-15-5

189.21

C11H11NO2

>98% (HPLC)

In Vitro:?1M HCl : 240 mg/mL (1268.43 mM; Ultrasonic; (HCL ，pH≈1) 1M NaOH : 240 mg/mL (1268.43 mM; ultrasonic and adjust pH to 11 with NaOH) DMSO : 2.22 mg/mL (11.73 mM; Ultrasonic )

N[C@@H](Cc1ccc(cc1)C#C)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years