p-Cresol

Research use only not for human use.

p-Cresol (4-methylphenol) is a partially lipophilic moiety which strongly binds to plasma protein (close to 100%) under normal conditions. p-Cresol is metabolized through conjugation mainly sulphation and glucuronization but removal of the unconjugated p-cresol is at least in part via the urine.

p-Cresol (4-methylphenol) is a partially lipophilic moiety which strongly binds to plasma protein (close to 100%) under normal conditions. p-Cresol is metabolized through conjugation mainly sulphation and glucuronization but removal of the unconjugated p-cresol is at least in part via the urine. Therefore it is not surprising that this compound together with several other phenoles is retained when the kidneys fail. P-Cresol is an end-product of protein breakdown and an increase of the nutritional protein load in healthy individuals results in enhanced generation and urinary excretion. The serum p-cresol concentration in uremic patients can be decreased by changing to a low-protein diet. p-Cresol is one of the metabolites of the amino acid tyrosine and to a certain extent also of phenylalanine which are converted to 4-hydroxyphenylacetic acid by intestinal bacteria before being decarboxylated to p-cresol (putrefaction).

4-Cresol;4-Methylphenol;4-Hydroxytoluene

Others

Other Targets

Others

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106-44-5

108.14

C7H8O

>98% (HPLC)

DMSO:10 mM

Cc1ccc(O)cc1

p-Cresol

(-20℃)

With Ice Pack

≥ 2 years