Cart
sales@molnova.com
Home - Products - Antibody Drug Conjugates (ADC) - ADCs Linker/Click Chemistry - m-PEG12-amine

m-PEG12-amine

CAS No. 1977493-48-3

m-PEG12-amine( —— )

Catalog No. M33419 CAS No. 1977493-48-3

m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 37 Get Quote
25MG 74 Get Quote
50MG 118 Get Quote
100MG 177 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    m-PEG12-amine
  • Note
    Research use only, not for human use.
  • Brief Description
    m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs and antibody-drug conjugates (ADCs) .
  • Description
    m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADCs Linker/Click Chemistry
  • Recptor
    ADC Linker
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1977493-48-3
  • Formula Weight
    559.69
  • Molecular Formula
    C25H53NO12
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (178.67 mM; Ultrasonic )
  • SMILES
    C(OCCOCCOCCOCCOCCOCCN)COCCOCCOCCOCCOCCOC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Aminooxy-PEG4-alcoho...

    Aminooxy-PEG4-alcohol is both a non-cleavable 4-unit PEG ADC linker and a PEG-based PROTAC linker.

  • 6-Maleimidohexanoic ...

    A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity; a useful protective group in antibody drug conjugates.

  • Boc-Val-Cit-PAB

    Boc-Val-Cit-PAB is a cleavable ADC linker. Boc-Val-Cit-PAB used in the synthesis of antibody-drug conjugates (ADCs).?

Sign In Join Free