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dCeMM2
CAS No. 296771-07-8
dCeMM2( —— )
Catalog No. M35561 CAS No. 296771-07-8
dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 47 | In Stock |
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| 5MG | 68 | In Stock |
|
| 10MG | 116 | In Stock |
|
| 25MG | 242 | In Stock |
|
| 50MG | 413 | In Stock |
|
| 100MG | 600 | In Stock |
|
| 500MG | 1278 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamedCeMM2
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NoteResearch use only, not for human use.
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Brief DescriptiondCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.
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DescriptiondCeMM2 (Compound 2) is a glue degrader. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMolecular Glues
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Research Area——
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Indication——
Chemical Information
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CAS Number296771-07-8
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Formula Weight370.82
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Molecular FormulaC16H11ClN6OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (112.37 mM; Ultrasonic (<60°C)
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SMILESClc1ccc(NC(=O)CSc2nnc3c(n2)[nH]c2ccccc32)nc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17(3):361]. Nat Chem Biol. 2020;16(11):1199-1207.?
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