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dBET6

CAS No. 1950634-92-0

dBET6( dBET 6 )

Catalog No. M13051 CAS No. 1950634-92-0

dBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    dBET6
  • Note
    Research use only, not for human use.
  • Brief Description
    dBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
  • Description
    dBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
  • In Vitro
    dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4.
  • In Vivo
    dBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL.
  • Synonyms
    dBET 6
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    BET
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1950634-92-0
  • Formula Weight
    841.381
  • Molecular Formula
    C42H45ClN8O7S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
  • Chemical Name
    6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Winter GE, et al. Mol Cell. 2017 Jul 6;67(1):5-18.e19. 2. Cancer Discov. 2017 Aug;7(8):794.
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