FKBP12 PROTAC dTAG-7( dTAG-7 )

Catalog No. M13208 CAS No. 2064175-32-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

FKBP12 PROTAC dTAG-7
Note

Research use only, not for human use.
Brief Description

FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN.
Description

FKBP12 PROTAC dTAG-7 (dTAG-7) is a cell-permeable heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN, selectively degrade FKBP12F36V in a CRBN-dependent manner in cells; causes rapid degradation of nuclear and cytoplasmic FKBP12F36V fusion chimeras.
In Vitro

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In Vivo

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Synonyms

dTAG-7
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

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Indication

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CAS Number

2064175-32-0
Formula Weight

1210.341
Molecular Formula

C63H79N5O19
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 150 mg/mL (123.93 mM)
SMILES

CCC(C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCCC2C(=O)OC(CCC3=CC(=C(C=C3)OC)OC)C4=CC=CC=C4OCC(=O)NCCCOCCOCCOCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O
Chemical Name

(1R)-3-(3,4-dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

1. Nabet B, et al. Nat Chem Biol. 2018 May;14(5):431-441.

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