cIAP1 E3 ligase inhibitor D19( cIAP1 inhibitor D19 )

Catalog No. M14312 CAS No. 380640-76-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

cIAP1 E3 ligase inhibitor D19
Note

Research use only, not for human use.
Brief Description

cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM.
Description

cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM, shows no effect on autoubiquitination of BRCA1/BARD1; binds to the RING domain of cIAP1 and inhibits the E3 ligase activity of cIAP1 by interfering with the dynamics of its interaction with E2, inhibited cIAP1 autoubiquitination with all of the E2s (t UbcH5a/b/c, UbcH6, and Ubc13/Uev1a) that can mediate its activity; suppresses c-MYC oncogenic function and cancer cell proliferation by stabilizing MAD1 protein and promoting the degradation of c-MYC.
In Vitro

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In Vivo

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Synonyms

cIAP1 inhibitor D19
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

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Indication

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CAS Number

380640-76-6
Formula Weight

325.404
Molecular Formula

C16H11N3OS2
Purity

>98% (HPLC)
Solubility

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SMILES

OC1=C(/C=N/NC2=NC3=CC=CC=C3S2)SC4=CC=CC=C41
Chemical Name

(E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)benzo[b]thiophen-3-ol

1. Li H, et al. Proc Natl Acad Sci U S A. 2018 Sep 4. pii: 201807711.

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