Zoliflodacin

CAS No. 1620458-09-4

Zoliflodacin ( ETX0914,AZD0914 )

Catalog No. M22420 CAS No. 1620458-09-4

Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 246 In Stock
10MG 389 In Stock
25MG 644 In Stock
50MG 888 In Stock
100MG 1233 In Stock
500MG 2457 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Zoliflodacin
  • Note
    Research use only, not for human use.
  • Brief Description
    Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).
  • Description
    Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA.
  • Synonyms
    ETX0914,AZD0914
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    Topoisomerase; DNA gyrase
  • Research Area
    Infection
  • Indication
    Gonorrhoea

Chemical Information

  • CAS Number
    1620458-09-4
  • Formula Weight
    487.44
  • Molecular Formula
    C22H20FN5O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:135 mg/mL (276.95 mM; Need ultrasonic)
  • SMILES
    [H][C@]12[C@H](C)O[C@H](C)CN1c1c(CC22C(=O)NC(=O)NC2=O)cc2c(noc2c1F)N1[C@@H](C)COC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Huband MD, et al. In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74.
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