Zoliflodacin
CAS No. 1620458-09-4
Zoliflodacin ( ETX0914,AZD0914 )
Catalog No. M22420 CAS No. 1620458-09-4
Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 246 | In Stock |
|
10MG | 389 | In Stock |
|
25MG | 644 | In Stock |
|
50MG | 888 | In Stock |
|
100MG | 1233 | In Stock |
|
500MG | 2457 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameZoliflodacin
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NoteResearch use only, not for human use.
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Brief DescriptionZoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).
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DescriptionZoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA.
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SynonymsETX0914,AZD0914
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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RecptorTopoisomerase; DNA gyrase
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Research AreaInfection
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IndicationGonorrhoea
Chemical Information
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CAS Number1620458-09-4
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Formula Weight487.44
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Molecular FormulaC22H20FN5O7
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Purity>98% (HPLC)
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SolubilityDMSO:135 mg/mL (276.95 mM; Need ultrasonic)
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SMILES[H][C@]12[C@H](C)O[C@H](C)CN1c1c(CC22C(=O)NC(=O)NC2=O)cc2c(noc2c1F)N1[C@@H](C)COC1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Huband MD, et al. In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74.
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