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Zanapezil
CAS No. 263248-42-6
Zanapezil( TAK-147 | TAK147 )
Catalog No. M13806 CAS No. 263248-42-6
Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1503 | Get Quote |
|
| 50MG | 3042 | Get Quote |
|
| 100MG | 4140 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameZanapezil
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NoteResearch use only, not for human use.
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Brief DescriptionZanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM.
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DescriptionZanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM; ameliorates the passive avoidance deficit induced by diazepam in animal models at 1-3 mg/kg, ameliorates the impairment of DMTP performance induced by scopolamine without affecting the general behavior of the rats.Alzheimer Disease Phase 3 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsTAK-147 | TAK147
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorAChE
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number263248-42-6
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Formula Weight492.616
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Molecular FormulaC29H36N2O5
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Purity>98% (HPLC)
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Solubility——
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SMILESC1CCNC2=C(C1)C=CC(=C2)C(=O)CCC3CCN(CC3)CC4=CC=CC=C4.C(=CC(=O)O)C(=O)O
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Chemical Name3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1- benzazepin-8-yl)-1-propanone fumarate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hatip-Al-Khatib I, et al. Br J Pharmacol. 2005 Aug;145(8):1035-44.
2. Hirai K, et al. J Pharmacol Exp Ther. 1997 Mar;280(3):1261-9.
3. Miyamoto M, et al. J Pharmacol Exp Ther. 1996 Jun;277(3):1292-304.
4. Ishihara Y, et al. J Med Chem. 1994 Jul 22;37(15):2292-9.
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