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ZYZ-488

CAS No. 1470302-79-4

ZYZ-488( ZYZ488 )

Catalog No. M12015 CAS No. 1470302-79-4

ZYZ-488 is a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ZYZ-488
  • Note
    Research use only, not for human use.
  • Brief Description
    ZYZ-488 is a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1).
  • Description
    ZYZ-488 is a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1), inhibits the activation of binding protein procaspase-9 and procaspase-3; exhibits cardioprotective effects on hypoxia-induced H9c2 rat ventricular cells, decreased apoptosis in hypoxic H9c2 cells, shows potential for treating cardiac ischemia.
  • In Vitro
    ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3. ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases.
  • In Vivo
    ZYZ-488 (33.9-67.8 mg/kg; intramuscularly; for 3 days) protected against myocardial apoptosis. Animal Model:Male C57BL/6 mice (8-10 weeks old).
  • Synonyms
    ZYZ488
  • Pathway
    Apoptosis
  • Target
    Apaf-1
  • Recptor
    Apaf-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1470302-79-4
  • Formula Weight
    487.462
  • Molecular Formula
    C20H29N3O11
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (410.29 mM)
  • SMILES
    ——
  • Chemical Name
    (2S,3S,4S,5R,6S)-6-(4-((4-guanidinobutoxy)carbonyl)-2,6-dimethoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang Y, et al. Sci Rep. 2016 Jul 22;6:29820. 2. Wang Y, et al. Oxid Med Cell Longev. 2017;2017:9747296.
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