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ZTM000990
CAS No. 115834-23-6
ZTM000990( SF 2446A1 )
Catalog No. M10549 CAS No. 115834-23-6
ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | In Stock |
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Biological Information
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Product NameZTM000990
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NoteResearch use only, not for human use.
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Brief DescriptionZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.
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DescriptionZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM; reduces levels of either c-Myc or cyclin D1 in HCT116 cells without effect on cyclin E levels, shows effects on growth of colon and prostate cancer cell lines (IC50=0.15-0.3 uM).
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In Vitro——
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In Vivo——
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SynonymsSF 2446A1
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorBeta-catenin
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Research Area——
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Indication——
Chemical Information
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CAS Number115834-23-6
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Formula Weight697.646
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Molecular FormulaC34H35NO15
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1C(C(C(C(O1)NC2=CC(=O)C3=C(C4=C(C=C3C2=O)C(=O)C5(C6=C(CC(C5(C4=O)OC)O)C=C(C(=C6O)C(=O)OC)C)O)O)OC)O)OC
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Chemical NameBenzo[a]naphthacene-2-carboxylic acid, 11-[(6-deoxy-2,4-di-O-methyl-b-L-mannopyranosyl)amino]-5,6,6a,7,9,12,14,14a-octahydro-1,6,8,14a-tetrahydroxy-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-, methyl ester, (6R,6aS,14aR)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lepourcelet M, et al. Cancer Cell. 2004 Jan;5(1):91-102.
2. Katoh M, et al. Clin Cancer Res. 2007 Jul 15;13(14):4042-5.
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