Cart
sales@molnova.com
ZM223
CAS No. 2031177-48-5
ZM223 ( ZM-223 )
Catalog No. M26524 CAS No. 2031177-48-5
ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 264 | Get Quote |
|
| 5MG | 403 | Get Quote |
|
| 10MG | 592 | Get Quote |
|
| 25MG | 888 | Get Quote |
|
| 50MG | 1242 | Get Quote |
|
| 100MG | 1701 | Get Quote |
|
| 500MG | 3402 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameZM223
-
NoteResearch use only, not for human use.
-
Brief DescriptionZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
-
DescriptionZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).(In Vitro):ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex.
-
SynonymsZM-223
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
RecptorEGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2031177-48-5
-
Formula Weight502.5
-
Molecular FormulaC23H17F3N4O2S2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESNc1ccc(SCC(=O)Nc2ccc3nc(NC(=O)c4ccc(cc4)C(F)(F)F)sc3c2)cc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Sargeant P, Farndale RW, Sage SO. ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. J Biol Chem. 1993 Aug 25;268(24):18151-6.
molnova catalog
related products
-
ZL0580
ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
-
MS645
MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
-
Oxyphencyclimine Hyd...
Oxyphencyclimine Hydrochloride is a synthetic tertiary amine and antimuscarinic agent with antispasmodic and antisecretory activities.
