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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - ZM223

ZM223

CAS No. 2031177-48-5

ZM223 ( ZM-223 )

Catalog No. M26524 CAS No. 2031177-48-5

ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 403 Get Quote
10MG 592 Get Quote
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Biological Information

  • Product Name
    ZM223
  • Note
    Research use only, not for human use.
  • Brief Description
    ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).
  • Description
    ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).(In Vitro):ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex.
  • Synonyms
    ZM-223
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2031177-48-5
  • Formula Weight
    502.5
  • Molecular Formula
    C23H17F3N4O2S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Nc1ccc(SCC(=O)Nc2ccc3nc(NC(=O)c4ccc(cc4)C(F)(F)F)sc3c2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sargeant P, Farndale RW, Sage SO. ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. J Biol Chem. 1993 Aug 25;268(24):18151-6.
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