ZK824190

CAS No. 2254001-81-3

ZK824190 ( —— )

Catalog No. M26523 CAS No. 2254001-81-3

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 512 Get Quote
10MG 734 Get Quote
25MG 1125 Get Quote
50MG 1512 Get Quote
100MG 2043 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    ZK824190
  • Note
    Research use only, not for human use.
  • Brief Description
    ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA).
  • Description
    ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.(In Vivo):In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2254001-81-3
  • Formula Weight
    414.4
  • Molecular Formula
    C22H20F2N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC[C@@H](Oc1nc(Oc2cccc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kilpatrick GJ, et al. 1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur J Pharmacol. 1990 Jun 21;182(1):193-7.
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