ZK824190

Research use only, not for human use.

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA).

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.(In Vivo):In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h.

——

ZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h). Animal Model:Rats with experimental autoimmune encephalomyelitis (EAE) model Dosage:2?mg/kg (Pharmacokinetic Analysis) Administration:PO Result:Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h.

——

Others

Other Targets

5-HT3

——

——

2254001-81-3

414.409

C22H20F2N2O4

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (603.28 mM)

CC[C@@H](Oc1nc(Oc2cccc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years