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ZK824190

CAS No. 2254001-81-3

ZK824190 ( —— )

Catalog No. M26523 CAS No. 2254001-81-3

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
5MG	512	Get Quote
10MG	734	Get Quote
25MG	1125	Get Quote
50MG	1512	Get Quote
100MG	2043	Get Quote
200MG	Get Quote	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

ZK824190
Note

Research use only, not for human use.
Brief Description

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA).
Description

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.(In Vivo):In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

5-HT3
Research Area

——
Indication

——

Chemical Information

CAS Number

2254001-81-3
Formula Weight

414.4
Molecular Formula

C22H20F2N2O4
Purity

>98% (HPLC)
Solubility

——
SMILES

CC[C@@H](Oc1nc(Oc2cccc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kilpatrick GJ, et al. 1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist. Eur J Pharmacol. 1990 Jun 21;182(1):193-7.

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