Yohimbine ( —— )

Catalog No. M11995 CAS No. 146-48-5

Yohimbine is an indole alkaloid that has high affinity for the α2-adrenergic receptors with Ki of 1 nM for α2A, α2B and α2C.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Yohimbine
Note

Research use only, not for human use.
Brief Description

Yohimbine is an indole alkaloid that has high affinity for the α2-adrenergic receptors with Ki of 1 nM for α2A, α2B and α2C.
Description

Yohimbine is an indole alkaloid that has high affinity for the α2-adrenergic receptors with Ki of 1 nM for α2A, α2B and α2C; shows moderate affinity for the α1 receptor, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2B, and D2 receptors, and weak affinity for the 5-HT1E, 5-HT2A, 5-HT5A, 5-HT7, and D3 receptors.
Synonyms

——
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

Neurological Disease
Indication

——

Chemical Information

CAS Number

146-48-5
Formula Weight

354.44
Molecular Formula

C21H26N2O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
Chemical Name

Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Millan MJ, et al. Synapse. 2000 Feb;35(2):79-95.
2. Arthur JM, et al. Biochem Pharmacol. 1993 Jun 9;45(11):2337-41.
3. Pérez Piero C, et al. Br J Pharmacol. 2012 May;166(2):721-36.
4. Baxter GS, et al. Br J Pharmacol. 1994 May;112(1):323-31.

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