YM17E

CAS No. 124900-72-7

YM17E ( —— )

Catalog No. M26512 CAS No. 124900-72-7

YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 101 Get Quote
10MG 141 Get Quote
25MG 235 Get Quote
50MG 347 Get Quote
100MG 518 Get Quote
500MG 1134 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    YM17E
  • Note
    Research use only, not for human use.
  • Brief Description
    YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
  • Description
    YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.(In Vitro):YM17E is potent in inhibiting ACAT activity in the intestine with IC50 of 34 nM.(In Vivo):YM17E inhibits the production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E (oral; i.v.) produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats. YM17E (3, 10, 30 mg/kg; p.o.) decreases total cholesterol, cholesteryl ester, and non-HDL cholesterol in a dose-dependent manner. YM17E (oral) decreases total cholesterol and cholesteryl ester levels in the liver significantly in a dose-dependent manner.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HCV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    124900-72-7
  • Formula Weight
    652.9
  • Molecular Formula
    C40H56N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN(C)c1ccc(NC(=O)N(Cc2cccc(CN(C3CCCCCC3)C(=O)Nc3ccc(cc3)N(C)C)c2)C2CCCCCC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Makonen Belema, et al. Hepatitis C virus inhibitors. US8329159B2.
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