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YM-58483
CAS No. 223499-30-7
YM-58483( YM58483 | YM 58483 | BPT2 )
Catalog No. M13583 CAS No. 223499-30-7
A store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 39 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 105 | In Stock |
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| 25MG | 215 | In Stock |
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| 50MG | 365 | In Stock |
|
| 100MG | 531 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameYM-58483
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NoteResearch use only, not for human use.
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Brief DescriptionA store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM.
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DescriptionA store-operated Ca2+ entry blocker and CRAC channel inhibitor with IC50 of 100 nM; inhibits Ca(2+) influx through SOC channels without affecting the TCR signal transduction cascade in Jurkat cells, inhibits thapsigargin-induced sustained Ca(2+) influx (IC50=100 nM), and 30-fold less potent against Cav channels; potently inhibits IL-2 production and NF-AT-driven promoter activity in Jurkat cells; also inhibits IL-4 and IL-5 production Th2 T cells, prevents antigen-induced inflammatory responses in animal models; orally active.
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In Vitro——
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In Vivo——
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SynonymsYM58483 | YM 58483 | BPT2
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PathwayMembrane Transporter/Ion Channel
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TargetCRAC Channel
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RecptorSOCE
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number223499-30-7
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Formula Weight421.3203
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Molecular FormulaC15H9F6N5OS
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESO=C(C1=C(C)N=NS1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2
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Chemical Name1,2,3-Thiadiazole-5-carboxamide, N-[4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ishikawa J, et al. J Immunol. 2003 May 1;170(9):4441-9.
2. Yoshino T, et al. Eur J Pharmacol. 2007 Apr 10;560(2-3):225-33.
3. Takezawa R, et al. Mol Pharmacol. 2006 Apr;69(4):1413-20.
4. Zitt C, et al. J Biol Chem. 2004 Mar 26;279(13):12427-37.
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