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YKL-05-099
CAS No. 1936529-65-5
YKL-05-099( YKL 05-099 )
Catalog No. M13037 CAS No. 1936529-65-5
YKL-05-099 (YKL 05-099) is a novel potent, selective pan-SIK inhibitor with IC50 of 10, 40 and 30 nM for SIK1, 2 and 3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | Get Quote |
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| 10MG | 205 | Get Quote |
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| 25MG | 357 | Get Quote |
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| 50MG | 530 | Get Quote |
|
| 100MG | 759 | Get Quote |
|
| 500MG | 1557 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameYKL-05-099
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NoteResearch use only, not for human use.
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Brief DescriptionYKL-05-099 (YKL 05-099) is a novel potent, selective pan-SIK inhibitor with IC50 of 10, 40 and 30 nM for SIK1, 2 and 3, respectively.
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DescriptionYKL-05-099 (YKL 05-099) is a novel potent, selective pan-SIK inhibitor with IC50 of 10, 40 and 30 nM for SIK1, 2 and 3, respectively; displays increased SIK selectivity and enhanced pharmacokinetic properties compared with HG-9-91-01; reduces LPS stimulated phosphorylation of HDAC5 at the SIK-specific phosphorylation site Ser259, increases expression of the CREB target genes Il10 and Nurr77, suppresses production of TNFα, IL-6 and IL-12p40 in BMDMs; a useful probe to investigate SIK function in vivo.
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In Vitro——
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In Vivo——
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SynonymsYKL 05-099
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PathwayAutophagy
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TargetSIK
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RecptorSIK
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Research Area——
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Indication——
Chemical Information
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CAS Number1936529-65-5
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Formula Weight600.11046
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Molecular FormulaC32H34ClN7O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 103.33 mg/mL; PBS: 100 mM
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SMILESO=C1N(C2=NC=C(OC)C=C2)C3=NC(NC4=CC=C(C5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6Cl
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Chemical NamePyrimido[4,5-d]pyrimidin-2(1H)-one, 3-(2-chloro-6-methylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-1-(5-methoxy-2-pyridinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sundberg TB, et al. ACS Chem Biol. 2016 Aug 19;11(8):2105-11.
2. Wein MN, et al. Nat Commun. 2016 Oct 19;7:13176.
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