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YKL-06-062
CAS No. 2172617-16-0
YKL-06-062( —— )
Catalog No. M33533 CAS No. 2172617-16-0
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that targets SIK1, SIK2, and SIK3, with IC50 values of 2.12 nM, 1.40 nM, and 2.86 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 141 | Get Quote |
|
| 5MG | 217 | Get Quote |
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| 10MG | 353 | Get Quote |
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| 25MG | 579 | Get Quote |
|
| 50MG | 824 | Get Quote |
|
| 100MG | 1098 | Get Quote |
|
| 500MG | 2205 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameYKL-06-062
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NoteResearch use only, not for human use.
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Brief DescriptionYKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that targets SIK1, SIK2, and SIK3, with IC50 values of 2.12 nM, 1.40 nM, and 2.86 nM, respectively.
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DescriptionYKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively.
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In VitroYKL 06-062 (0.0004-16 μM; 3 hours) increases MITF mRNA expression in a dose-dependent manner.:RT-PCR Cell Line:Human melanocyte cells, UACC62 melanoma cells Concentration:0.0004 μM, 0.004 μM, 0.04 μM, 0.4 μM, 4 μM,8 μM,16 μM Incubation Time:3 hours Result:Unregulated MITF mRNA expression.
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetSIK
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RecptorSIK
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Research Area——
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Indication——
Chemical Information
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CAS Number2172617-16-0
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Formula Weight525.69
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Molecular FormulaC31H39N7O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (47.56 mM; Ultrasonic )
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SMILESCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C4CCCCC4)c3n2)c2c(C)cccc2C)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184.?
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