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YKL-06-062

CAS No. 2172617-16-0

YKL-06-062( —— )

Catalog No. M33533 CAS No. 2172617-16-0

YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that targets SIK1, SIK2, and SIK3, with IC50 values of 2.12 nM, 1.40 nM, and 2.86 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 217 Get Quote
10MG 353 Get Quote
25MG 579 Get Quote
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Biological Information

  • Product Name
    YKL-06-062
  • Note
    Research use only, not for human use.
  • Brief Description
    YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that targets SIK1, SIK2, and SIK3, with IC50 values of 2.12 nM, 1.40 nM, and 2.86 nM, respectively.
  • Description
    YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively.
  • In Vitro
    YKL 06-062 (0.0004-16 μM; 3 hours) increases MITF mRNA expression in a dose-dependent manner.:RT-PCR Cell Line:Human melanocyte cells, UACC62 melanoma cells Concentration:0.0004 μM, 0.004 μM, 0.04 μM, 0.4 μM, 4 μM,8 μM,16 μM Incubation Time:3 hours Result:Unregulated MITF mRNA expression.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    SIK
  • Recptor
    SIK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2172617-16-0
  • Formula Weight
    525.69
  • Molecular Formula
    C31H39N7O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (47.56 mM; Ultrasonic )
  • SMILES
    CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C4CCCCC4)c3n2)c2c(C)cccc2C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184.?
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