YK-4-279 ( YK-4-279; YK4-279; YK 4-279; YK 4279 )

Catalog No. M17770 CAS No. 1037184-44-3

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Product Name

YK-4-279
Note

Research use only, not for human use.
Brief Description

YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.
Description

YK-4-279 is a ETV1 inhibitor, which inhibitor protein-protein interactions between ES-FLI1 and RHA.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model.
Synonyms

YK-4-279; YK4-279; YK 4-279; YK 4279
Pathway

Others
Target

Other Targets
Recptor

RNA helicase A
Research Area

Cancer
Indication

——

CAS Number

1037184-44-3
Formula Weight

366.2
Molecular Formula

C17H13Cl2NO4
Purity

98%
Solubility

DMSO : 25 mg/mL. 68.27 mM;
SMILES

COC1=CC=C(C=C1)C(=O)CC1(O)C(=O)NC2=C(Cl)C=CC(Cl)=C12
Chemical Name

4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-one

1. Erkizan HV, et al. Nat Med. 2009, 15(7), 750-756.2. Rahim S, et al. PLoS One. 2011, 6(4), e19343.

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