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Home - Products - Membrane Transporter/Ion Channel - BCRP - YHO-13177

YHO-13177

CAS No. 912287-56-0

YHO-13177( YHO13177 )

Catalog No. M16545 CAS No. 912287-56-0

YHO-13177 is a acrylonitrile derivative and active form of YHO-13351 that can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    YHO-13177
  • Note
    Research use only, not for human use.
  • Brief Description
    YHO-13177 is a acrylonitrile derivative and active form of YHO-13351 that can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo.
  • Description
    YHO-13177 is a acrylonitrile derivative and active form of YHO-13351 that can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo; reverses BCRP-mediated acquired resistance to SN-38 in A549 cells without cytotoxicity, also shows no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1-mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    YHO13177
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    BCRP
  • Recptor
    others
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    912287-56-0
  • Formula Weight
    370.4653
  • Molecular Formula
    C20H22N2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    N#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(O)CC3)S2
  • Chemical Name
    Benzeneacetonitrile, α-[[5-(4-hydroxy-1-piperidinyl)-2-thienyl]methylene]-3,4-dimethoxy-, (αZ)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yamazaki R, et al. Mol Cancer Ther. 2011 Jul;10(7):1252-63.
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