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Home - Products - Membrane Transporter/Ion Channel - BCRP - Ko-143

Ko-143

CAS No. 461054-93-3

Ko-143( Ko143 )

Catalog No. M14552 CAS No. 461054-93-3

A nontoxic analog of fungal toxin fumitremorgin C and potent, orally bioavailable inhibitor of BCRP (ABCG2) with EC90 of 26 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ko-143
  • Note
    Research use only, not for human use.
  • Brief Description
    A nontoxic analog of fungal toxin fumitremorgin C and potent, orally bioavailable inhibitor of BCRP (ABCG2) with EC90 of 26 nM.
  • Description
    A nontoxic analog of fungal toxin fumitremorgin C and potent, orally bioavailable inhibitor of BCRP (ABCG2) with EC90 of 26 nM; shows low activity against P-gp, MRP1 and other known drug transporter; has an effect on the transport activity of both ABCB1 and ABCC1 at >1 uM; reverses Bcrp-mediated drug resistance and markedly increases the oral availability of topotecan in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Ko143
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    BCRP
  • Recptor
    BCRP
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    461054-93-3
  • Formula Weight
    469.5732
  • Molecular Formula
    C26H35N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(OC(C)(C)C)CC[C@@H]1NC([C@]2([H])CC3=C([C@H](CC(C)C)N2C1=O)NC4=C3C=CC(OC)=C4)=O
  • Chemical Name
    Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Allen JD, et al. Mol Cancer Ther. 2002 Apr;1(6):417-25. 2. Weidner LD, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):384-93. 3. Ozvegy-Laczka C, et al. J Biol Chem. 2005 Feb 11;280(6):4219-27. 4. Elkind NB, et al. Cancer Res. 2005 Mar 1;65(5):1770-7.
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