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Home - Products - Nuclear Receptor/Transcription Factor - CREB/CBP - XX-650-23

XX-650-23

CAS No. 117739-40-9

XX-650-23( XX 650 23 )

Catalog No. M10601 CAS No. 117739-40-9

XX-650-23?is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    XX-650-23
  • Note
    Research use only, not for human use.
  • Brief Description
    XX-650-23?is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression.
  • Description
    XX-650-23?is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    XX 650 23
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    CREB/CBP
  • Recptor
    CREB/CBP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    117739-40-9
  • Formula Weight
    288.306
  • Molecular Formula
    C18H12N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (346.86 mM)
  • SMILES
    O=C(NC1=CC=C(C#N)C=C1)C2=C(O)C=C3C=CC=CC3=C2
  • Chemical Name
    N-(4-cyanophenyl)-3-hydroxy-2-naphthamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mitton B, et al. Leukemia. 2016 Dec;30(12):2302-2311. 2. Fran?ois S, et al. J Virol. 2016 Sep 12;90(19):8686-97.
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