XRK3F2( —— )

Catalog No. M16928 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

XRK3F2
Note

Research use only, not for human use.
Brief Description

XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells.
Description

XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells; inhibits TNFα-induced osteoclast formation, and has IC50 of 4.35 uM 5TGM1 cells and 4.6 uM for the human MM1.S cell line; induces new cortical bone formation in MMBD in vivo, and alters MM cell-BMSC cell interactions by reducing MM cell-derived TNFα in the myeloma microenvironment.
In Vitro

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In Vivo

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Synonyms

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Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

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Indication

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CAS Number

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Formula Weight

435.896
Molecular Formula

C23H24ClF2NO3
Purity

>98% (HPLC)
Solubility

——
SMILES

CN(CCO)C1=CC=C(OCC2=CC=C(F)C=C2)C(OCC3=CC=C(F)C=C3)=C1.[H]Cl
Chemical Name

2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride

1. Teramachi J, et al. Leukemia. 2016 Feb;30(2):390-8. 2.?Adamik J, et al. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.

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