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XMD8-92
CAS No. 1234480-50-2
XMD8-92( XMD8-92 | XMD-8-92 | XMD 8-92 | XMD892 )
Catalog No. M10935 CAS No. 1234480-50-2
XMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 120 | In Stock |
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| 50MG | 222 | In Stock |
|
| 100MG | 372 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameXMD8-92
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NoteResearch use only, not for human use.
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Brief DescriptionXMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM.
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DescriptionXMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM.
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In VitroCell Viability Assay Cell Line:HMEC, A549 and HeLa cells Concentration:0.16, 0.32, 0.63, 1.25, 2.5 or 5 μM Incubation Time:48 hours Result:Inhibited the proliferation of HMEC and cancer cells.
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In VivoAnimal Model:HeLa Xenograft Model (6-week-old Nod/Scid mice)Dosage:50 mg/kg Administration:I.p.; twice a day for 28 days Result:Significantly inhibited the growth of the xenografted human tumors.
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SynonymsXMD8-92 | XMD-8-92 | XMD 8-92 | XMD892
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PathwayOthers
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TargetBMI-1
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RecptorBMI-1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1234480-50-2
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Formula Weight474.55
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Molecular FormulaC26H30N6O3
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Purity>98% (HPLC)
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SolubilityDMSO: 73 mg/mL warmed (153.82 mM)
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SMILESO=C1N(C)C2=CN=C(NC3=CC=C(N4CCC(O)CC4)C=C3OCC)N=C2N(C)C5=CC=CC=C15
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Chemical Name2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sureban SM, et al. Y Lett. 2014 , 351(1), 151-16
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