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Home - Products - Endocrinology/Hormones - Estrogen Receptor/ERR - XCT790

XCT790

CAS No. 725247-18-7

XCT790 ( XCT 790;XCT-790 )

Catalog No. M15777 CAS No. 725247-18-7

A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    XCT790
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
  • Description
    A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays; shows no significant antagonist activity on related nuclear receptors (ERRγ or ERα, LXRα, LXRβ, FXR, PPARα, PPARδ, PPARγ, Nurr1, RARα, RORα, and RXRα) at 10 uM; inhibits PGC-1α regulation of ERRα and ERRα target gene expression; inhibits proliferation in cellular models of breast cancer.
  • Synonyms
    XCT 790;XCT-790
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    ERRα
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    725247-18-7
  • Formula Weight
    596.42
  • Molecular Formula
    C23H13F9N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 21 mg/mL
  • SMILES
    O=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=CC=C(C(F)(F)F)C=C3C(F)(F)F)C(OC)=C2
  • Chemical Name
    2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Willy PJ, et al. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7.

2. Busch BB, et al. J Med Chem. 2004 Nov 4;47(23):5593-6.

3. Lanvin O, et al. J Biol Chem. 2007 Sep 28;282(39):28328-34.

4. Chang CY, et al. Cancer Cell. 2011 Oct 18;20(4):500-10.
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