XCT790
CAS No. 725247-18-7
XCT790 ( XCT 790;XCT-790 )
Catalog No. M15777 CAS No. 725247-18-7
A potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 53 | In Stock |
|
10MG | 88 | In Stock |
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25MG | 170 | In Stock |
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50MG | 311 | In Stock |
|
100MG | 462 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameXCT790
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays.
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DescriptionA potent and selective ERRα inverse agonist with IC50 of 300-500 nM in transient transfection assays; shows no significant antagonist activity on related nuclear receptors (ERRγ or ERα, LXRα, LXRβ, FXR, PPARα, PPARδ, PPARγ, Nurr1, RARα, RORα, and RXRα) at 10 uM; inhibits PGC-1α regulation of ERRα and ERRα target gene expression; inhibits proliferation in cellular models of breast cancer.
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SynonymsXCT 790;XCT-790
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorERRα
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number725247-18-7
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Formula Weight596.42
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Molecular FormulaC23H13F9N4O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 21 mg/mL
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SMILESO=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=CC=C(C(F)(F)F)C=C3C(F)(F)F)C(OC)=C2
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Chemical Name2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Willy PJ, et al. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7.
2. Busch BB, et al. J Med Chem. 2004 Nov 4;47(23):5593-6.
3. Lanvin O, et al. J Biol Chem. 2007 Sep 28;282(39):28328-34.
4. Chang CY, et al. Cancer Cell. 2011 Oct 18;20(4):500-10.
2. Busch BB, et al. J Med Chem. 2004 Nov 4;47(23):5593-6.
3. Lanvin O, et al. J Biol Chem. 2007 Sep 28;282(39):28328-34.
4. Chang CY, et al. Cancer Cell. 2011 Oct 18;20(4):500-10.
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