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Wortmannin
CAS No. 19545-26-7
Wortmannin ( SL-2052;KY-12420 )
Catalog No. M13060 CAS No. 19545-26-7
A potent PI3K inhibitor with IC50 3 nM, does not inhibit PI4K activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 65 | In Stock |
|
| 10MG | 87 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameWortmannin
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NoteResearch use only, not for human use.
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Brief DescriptionA potent PI3K inhibitor with IC50 3 nM, does not inhibit PI4K activity.
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DescriptionA potent PI3K inhibitor with IC50 3 nM, does not inhibit PI4K activity; inhibits both Fc epsilon RI-mediated histamine secretion and leukotriene release up to 80% with IC50 of 2.0 and 3.0 nM, respectively; Also inhibits DNA-PK and MLCK.
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SynonymsSL-2052;KY-12420
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K,DNA-PK,ATM,MLCK,ATR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number19545-26-7
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Formula Weight428.43
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Molecular FormulaC23H24O8
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(O[C@@H](C1=C2C(C3=C4C(C(O[C@H](COC)[C@]14C)=O)=CO3)=O)C[C@]5(C)C(CC[C@]52[H])=O)=O
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Chemical Name3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yano H, et al. J Biol Chem. 1993 Dec 5;268(34):25846-56.
2. Nakanishi S, et al. J Biol Chem. 1992 Feb 5;267(4):2157-63.
3. Nakanishi S, et al. J Biol Chem. 1994 Mar 4;269(9):6528-35.
4. Boulton S, et al. Carcinogenesis. 1996 Nov;17(11):2285-90.
2. Nakanishi S, et al. J Biol Chem. 1992 Feb 5;267(4):2157-63.
3. Nakanishi S, et al. J Biol Chem. 1994 Mar 4;269(9):6528-35.
4. Boulton S, et al. Carcinogenesis. 1996 Nov;17(11):2285-90.
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