WZ4002 ( WZ4002; WZ-4002; WZ 4002 )

Catalog No. M10796 CAS No. 1213269-23-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

WZ4002
Note

Research use only, not for human use.
Brief Description

WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM.
Description

WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I).
Synonyms

WZ4002; WZ-4002; WZ 4002
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR (L858R); EGFR (L858R/T790M)
Research Area

Cancer
Indication

——

CAS Number

1213269-23-8
Formula Weight

494.18
Molecular Formula

C25H27ClN6O3
Purity

>98%(HPLC)
Solubility

DMSO:13 mg/mL (26.3 mM);Ethanol:<1 mg/mL (<1 mM);Water：<1 mg/mL (<1 mM)
SMILES

C=CC(NC1=CC=CC(OC2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3OC)=NC=C2Cl)=C1)=O
Chemical Name

N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide

1.Zhou W, et al. Nature. 2009, 462(7276), 1070-1074.

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