Alflutinib( AST2818 | AST-2818 | ASK120067 )

Catalog No. M12888 CAS No. 1869057-83-9

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Product Name

Alflutinib
Note

Research use only, not for human use.
Brief Description

Alflutinib (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor.
Description

Alflutinib (AST-2818, ASK120067) is a third generation EGFR mutation selective tyrosine kinase inhibitor, inhibits EGFR active mutations as well as T790M acquired resistant mutation.Lung Cancer Phase 1 Clinical.
In Vitro

Firmonertinib is designed to inhibit EGFR active mutations as well as the T790M acquired resistant mutation.
In Vivo

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Synonyms

AST2818 | AST-2818 | ASK120067
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

Cancer
Indication

Lung Cancer

CAS Number

1869057-83-9
Formula Weight

568.605
Molecular Formula

C28H31F3N8O2
Purity

>98% (HPLC)
Solubility

——
SMILES

CN(C)CCN(C)c1nc(OCC(F)(F)F)c(Nc2nccc(n2)c3cn(C)c4ccccc34)cc1NC(=O)C=C
Chemical Name

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)acrylamide

1. PCT Int. Appl. (2017), WO 2017152707 A1 20170914.

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