WZ3146
CAS No. 1214265-56-1
WZ3146 ( WZ3146; WZ-3146; WZ 3146 )
Catalog No. M17196 CAS No. 1214265-56-1
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 61 | In Stock |
|
5MG | 88 | In Stock |
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10MG | 170 | In Stock |
|
25MG | 302 | In Stock |
|
50MG | 483 | In Stock |
|
100MG | 691 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameWZ3146
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NoteResearch use only, not for human use.
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Brief DescriptionWZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
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DescriptionWZ-3146 is a covalent or irreversible pyrimidine-based EGFR inhibitor against EGFR T790M. WZ-3146 was identified by screening an irreversible kinase inhibitor library specifically against EGFR T790M. WZ-3146 potently suppresses the growth of EGFR-T790M-containing cell lines and inhibits EGFR phosphorylation. WZ-3146 is also effective in murine models of lung cancer driven by EGFR T790M. WZ-3146 may be clinically more effective and better tolerated than quinazoline-based inhibitors. All current EGFR inhibitors possess a structurally related quinazoline-based core scaffold and were identified as ATP-competitive inhibitors of wild-type EGFR.
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SynonymsWZ3146; WZ-3146; WZ 3146
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PathwayOthers
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TargetOther Targets
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RecptorEGFR (E746_A750); EGFR (E746_A750/T790M); EGFR (L858R); EGFR (L858R/T790M)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1214265-56-1
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Formula Weight464.95
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Molecular FormulaC24H25ClN6O2
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Purity98%
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SolubilityDMSO : 150 mg/mL. 322.62 mM;
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SMILESCN1CCN(CC1)C1=CC=C(NC2=NC=C(Cl)C(OC3=CC(NC(=O)C=C)=CC=C3)=N2)C=C1
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Chemical NameN-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhou W, et al. Nature, 2009, 462(7276), 1070-1074.
molnova catalog
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