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Home - Products - Tyrosine Kinase - c-Fes Kinase - WZ-4-49-8

WZ-4-49-8

CAS No. 1125594-27-5

WZ-4-49-8( WZ-4-49-8 | WZ 4 49 8 | WZ4498 )

Catalog No. M10441 CAS No. 1125594-27-5

WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    WZ-4-49-8
  • Note
    Research use only, not for human use.
  • Brief Description
    WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM.
  • Description
    WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM; displays an exceptional selectivity profile with a selectivity score of only 0.027 in a panel of 442 kinases; inhibits c-Fes-L145P autophosphorylation and microtubule association in at least a subset of cells, and potently inhibits c-Fes-L145P-mediated soft-agar colony growth; dramatically inhibits osteoclast differentiation in RAW 264.7 macrophage cell line.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    WZ-4-49-8 | WZ 4 49 8 | WZ4498
  • Pathway
    Tyrosine Kinase
  • Target
    c-Fes Kinase
  • Recptor
    c-Fes Kinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1125594-27-5
  • Formula Weight
    618.801
  • Molecular Formula
    C32H42N8O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=S(C1=CC=CC=C1NC2=C3C(NN=C3)=NC(NC4=CC=C(N5CCC(N6CCCCC6)CC5)C=C4OCC)=N2)(C(C)C)=O
  • Chemical Name
    N6-(4-[1,4'-Bipiperidin]-1'-yl-2-ethoxyphenyl)-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40. 2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178.
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  • WZ-4-49-8

    WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM.

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