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WHI-P180

CAS No. 211555-08-7

WHI-P180( Janex 3 )

Catalog No. M13366 CAS No. 211555-08-7

WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    WHI-P180
  • Note
    Research use only, not for human use.
  • Brief Description
    WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
  • Description
    WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
  • In Vitro
    ——
  • In Vivo
    WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.
  • Synonyms
    Janex 3
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK2| EGFR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    211555-08-7
  • Formula Weight
    297.31
  • Molecular Formula
    C16H15N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    OC1=CC=CC(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1
  • Chemical Name
    3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.An R, et al. Pharm Res. 2009 Feb;26(2):449-58.
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