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WHI-P180
CAS No. 211555-08-7
WHI-P180( Janex 3 )
Catalog No. M13366 CAS No. 211555-08-7
WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 51 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 124 | In Stock |
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| 25MG | 210 | In Stock |
|
| 50MG | 311 | In Stock |
|
| 100MG | 461 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameWHI-P180
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NoteResearch use only, not for human use.
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Brief DescriptionWHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
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DescriptionWHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
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In Vitro——
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In VivoWHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.
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SynonymsJanex 3
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK2| EGFR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number211555-08-7
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Formula Weight297.31
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Molecular FormulaC16H15N3O3
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESOC1=CC=CC(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1
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Chemical Name3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.An R, et al. Pharm Res. 2009 Feb;26(2):449-58.
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