MSC-2530818

CAS No. 1883423-59-3

MSC-2530818 ( MSC 2530818;MSC2530818 )

Catalog No. M12925 CAS No. 1883423-59-3

MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 132 Get Quote
10MG 218 Get Quote
25MG 482 Get Quote
50MG 696 Get Quote
100MG 972 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    MSC-2530818
  • Note
    Research use only, not for human use.
  • Brief Description
    MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
  • Description
    MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM; binds to CDK8 and CDK19 with similar affinity (4 nM), and displays good selectivity profile in a 264 kinase panel with exception of GSK3α (IC50=691 nM); potently inhibits of phospho-STAT1 S727 in SW620 cells (IC50=8 nM), shows potent inhibition of WNT-dependent transcription in human cancer cell lines; demonstrates tumor growth inhibition in an APC mutant SW620 human colorectal carcinoma xenograft model.
  • Synonyms
    MSC 2530818;MSC2530818
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1883423-59-3
  • Formula Weight
    340.81
  • Molecular Formula
    C18H17ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 366.77 mM
  • SMILES
    O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
  • Chemical Name
    [(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Czodrowski P, et al. J Med Chem. 2016 Oct 27;59(20):9337-9349.
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