MSC-2530818
CAS No. 1883423-59-3
MSC-2530818 ( MSC 2530818;MSC2530818 )
Catalog No. M12925 CAS No. 1883423-59-3
MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 132 | Get Quote |
|
10MG | 218 | Get Quote |
|
25MG | 482 | Get Quote |
|
50MG | 696 | Get Quote |
|
100MG | 972 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMSC-2530818
-
NoteResearch use only, not for human use.
-
Brief DescriptionMSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
-
DescriptionMSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM; binds to CDK8 and CDK19 with similar affinity (4 nM), and displays good selectivity profile in a 264 kinase panel with exception of GSK3α (IC50=691 nM); potently inhibits of phospho-STAT1 S727 in SW620 cells (IC50=8 nM), shows potent inhibition of WNT-dependent transcription in human cancer cell lines; demonstrates tumor growth inhibition in an APC mutant SW620 human colorectal carcinoma xenograft model.
-
SynonymsMSC 2530818;MSC2530818
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1883423-59-3
-
Formula Weight340.81
-
Molecular FormulaC18H17ClN4O
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 125 mg/mL 366.77 mM
-
SMILESO=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
-
Chemical Name[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Czodrowski P, et al. J Med Chem. 2016 Oct 27;59(20):9337-9349.
molnova catalog
related products
-
Ro-3306
Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively.
-
NG-52
NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase.
-
GW779439X
GW779439X is an inhibitor of CDK.