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MSC-2530818

CAS No. 1883423-59-3

MSC-2530818 ( MSC 2530818;MSC2530818 )

Catalog No. M12925 CAS No. 1883423-59-3

MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MSC-2530818
  • Note
    Research use only, not for human use.
  • Brief Description
    MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM.
  • Description
    MSC-2530818 (MSC 2530818, MSC2530818) is a potent, selective, and orally bioavailable CDK8 inhibitor with IC50 of 2.6 nM; binds to CDK8 and CDK19 with similar affinity (4 nM), and displays good selectivity profile in a 264 kinase panel with exception of GSK3α (IC50=691 nM); potently inhibits of phospho-STAT1 S727 in SW620 cells (IC50=8 nM), shows potent inhibition of WNT-dependent transcription in human cancer cell lines; demonstrates tumor growth inhibition in an APC mutant SW620 human colorectal carcinoma xenograft model.
  • Synonyms
    MSC 2530818;MSC2530818
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1883423-59-3
  • Formula Weight
    340.81
  • Molecular Formula
    C18H17ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 366.77 mM
  • SMILES
    O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
  • Chemical Name
    [(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Czodrowski P, et al. J Med Chem. 2016 Oct 27;59(20):9337-9349.
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