Cart
sales@molnova.com
WAY-213613
CAS No. 868359-05-1
WAY-213613( —— )
Catalog No. M24877 CAS No. 868359-05-1
WAY-213613 is a potent and selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 (IC50: 85 nM EAAT2).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 189 | In Stock |
|
| 10MG | 285 | In Stock |
|
| 25MG | 505 | In Stock |
|
| 50MG | 759 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameWAY-213613
-
NoteResearch use only, not for human use.
-
Brief DescriptionWAY-213613 is a potent and selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 (IC50: 85 nM EAAT2).
-
DescriptionWAY-213613 is a potent and selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 (IC50: 85 nM EAAT2). It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s: 5 and 3.8 μM, respectively). WAY-213613 shows no activity at ionotropic and metabotropic glutamate receptors.
-
In VitroWAY-213613 (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC50 values of 5004 nM, 85 nM and 3787 nM, respectively.WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[3H] glutamate uptake with Ki values of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively.WAY-213613 (0-100 μM) produces a concentration-dependent block of glutamate-induced currents in EAAT1-, EAAT2- or EAAT3-injected oocytes, with IC50 values of 48, 0.13 and 4.0 μM, respectively.WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses.
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorEAAT2|EAAT3|EAAT1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number868359-05-1
-
Formula Weight415.19
-
Molecular FormulaC16H13BrF2N2O4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN[C@@H](CC(Nc(cc1)ccc1Oc(cc(c(F)c1)F)c1Br)=O)C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.
molnova catalog
related products
-
N-Benzyloleamide
N-(3-Methoxybenzyl)Oleamide, an agmatine isolated from Lepidium meyenii, has pharmacological effects on exercise-induced fatigue, which may be related to the modulation of energy metabolism and improvement of antioxidant status.
-
5-HYDROXYINDOLE-3-AC...
5-Hydroxyindoleacetic acid (5HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors and levels of these substances may be measured in the urine to test for carcinoid tumors (NCI).
-
DNP
24-dinitrophenol is a toxic dye chemically related to trinitrophenol (picric acid) used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation.
