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Voruciclib
CAS No. 1000023-04-0
Voruciclib ( P 1446;P 1446A )
Catalog No. M10001 CAS No. 1000023-04-0
A potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 410 | Get Quote |
|
| 10MG | 591 | Get Quote |
|
| 25MG | 888 | Get Quote |
|
| 50MG | 1224 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVoruciclib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively.
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DescriptionA potent, selective and orally bioavailable CDK9 inhibitor with Ki of 0.63 nM and 1.68 nM for CDK9/cyclinT2 and CDK9/cyclinT1, respectively; also inhibits CDK6/cyclin D1, CDK4/cyclin D1, CDK1/cyclin B and CDK1/cyclin A with Ki of 3-10 nM, shows weak activity against MAK and ICK (Ki>250 nM); exhibits more selective target profile than flavopiridol, represses MCL-1 protein expression in preclinical models of DLBCL, causes tumor cell apoptosis and tumor growth inhibition combined with venetoclax in vivo.Blood Cancer Phase 1 Clinical
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SynonymsP 1446;P 1446A
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1000023-04-0
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Formula Weight469.84
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Molecular FormulaC22H19ClF3NO5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C(O)=CC(O)=C13
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Chemical Name2-[2-Chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dey J, et al. Sci Rep. 2017 Dec 21;7(1):18007.
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