M2I-1

CAS No. 312271-03-7

M2I-1 ( Mad2 inhibitor 1 )

Catalog No. M13998 CAS No. 312271-03-7

The first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 58 In Stock
5MG 110 In Stock
10MG 178 In Stock
25MG 410 In Stock
50MG 605 In Stock
100MG 860 In Stock
500MG 1728 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    M2I-1
  • Note
    Research use only, not for human use.
  • Brief Description
    The first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2.
  • Description
    The first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20; equally potent in inhibiting the binding of F-Mbp1 to Mad2; disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20, weakens the spindle assembly checkpoint (SAC) response.
  • Synonyms
    Mad2 inhibitor 1
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    312271-03-7
  • Formula Weight
    404.48
  • Molecular Formula
    C19H24N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 32 mg/mL
  • SMILES
    O=C(/C(C(N1)=O)=C\C2=CC=C(N(CC(C)C)CC(C)C)C([N+]([O-])=O)=C2)NC1=S
  • Chemical Name
    4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kastl J, et al. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.
molnova catalog
related products
  • Cdc7 inhibitor 7c

    A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively.

  • Roscovitine

    A potent and selective CDK inhibitor with IC50 of 0.2 uM, 0.65 uM, and 0.7 uM for CDK5, Cdc2, and CDK2, respectively.

  • Riviciclib

    A novel potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.