Vidofludimus ( Vidofludimus; 4SC 101; 4SC101; SC12267 )

Catalog No. M17579 CAS No. 717824-30-1

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Product Name

Vidofludimus
Note

Research use only, not for human use.
Brief Description

Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
Description

Vidofludimus, also known as 4SC 101 or SC12267, is a novel orally active and potent DHODH inhibitor. In vitro, 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes. In vivo, oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. 4SC-101 may have potential for the treatment of intestinal inflammation. Dihydroorotate dehydrogenase (DHODH) is a key enzyme involved in pyrimidine biosynthesis. DHODH is a known target for the treatment of autoimmune diseases.
Synonyms

Vidofludimus; 4SC 101; 4SC101; SC12267
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

Human DHODH
Research Area

Inflammation/Immunology
Indication

——

CAS Number

717824-30-1
Formula Weight

355.36
Molecular Formula

C20H18FNO4
Purity

98%
Solubility

DMSO : ≥ 46 mg/mL; 129.45 mM
SMILES

COc1cccc(c1)c1cc(F)c(NC(=O)C2=C(CCC2)C(=O)O)cc1
Chemical Name

2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamoyl)cyclopent-1-enecarboxylic acid

1. Kulkarni OP, et al. Am J Pathol. 2010 Jun;176(6):2840-7.

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