
Venadaparib
CAS No. 1681017-83-3
Venadaparib( IDX-1197 | NOV140101 )
Catalog No. M28681 CAS No. 1681017-83-3
Venadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 51 | Get Quote |
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5MG | 87 | Get Quote |
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10MG | 132 | Get Quote |
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25MG | 267 | Get Quote |
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50MG | 439 | Get Quote |
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100MG | 644 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameVenadaparib
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NoteResearch use only, not for human use.
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Brief DescriptionVenadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
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DescriptionVenadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSBs) and can be used in solid tumor research.(In Vitro):Venadaparib significantly inhibits PARP1-mediated PAR expression with an EC50?of 0.5 nM In DNA damage-induced Hela cells.(In Vivo):Oral administration of Venadaparib significantly inhibits PAR(>90%) in tumor tissues until 24 hr post-dose in the germline BRCA1-mutated ovarian cancer PDX model. Venadaparib also dose-dependently inhibits potent tumor growth compared to the Olaparib treatment group.
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In VitroIn DNA damage-induced Hela cells, Venadaparib (IDX-1197) significantly inhibits PARP1-mediated PAR expression (EC50 of 0.5 nM).
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In VivoIn the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group.
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SynonymsIDX-1197 | NOV140101
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PathwayCell Cycle/DNA Damage
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TargetPARP
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1681017-83-3
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Formula Weight406.461
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Molecular FormulaC23H23FN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (246.03 mM)
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SMILESFc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CC(CNC2CC2)C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Helmut Dr. Hettche, et al. Aerosol compositions containing compound D-18024 and its analogs. EP 0561166 A1.
molnova catalog



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