Vasopressin

Research use only, not for human use.

Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis.

Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.

AVP (0.01 nM-1 μM) induces Ca2+ increase in Chinese hamster ovary cells expressing rat or human V1b receptors.

Vasopressin (0.03-0.3μg/kg; i.p.) potentiates corticotropin release provoked by exogenous corticoliberin and increases corticotropin secretion subsequent to body water loss.Vasopressin (0.001-0.1?mg/kg; i.p.) potently increases adjacent lying, where rats meeting for the first time lie passively next to each other.

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Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite

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11000-17-2

1084.24

C46H65N15O12S2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (92.23 mM; Ultrasonic ) H2O : 50 mg/mL (46.12 mM; Ultrasonic)

O=C([C@@H](N)CSSC[C@H](NC1=O)C(N2[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCNC(N)=N)=O)CCC2)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CC(N)=O)=O)CCC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4

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(-20℃)

With Ice Pack

≥ 2 years