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Vandetanib

CAS No. 443913-73-3

Vandetanib ( ZD6474 )

Catalog No. M14519 CAS No. 443913-73-3

Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability.

Purity : >98%(HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
10MG	41	In Stock
25MG	57	In Stock
50MG	88	In Stock
100MG	160	In Stock
200MG	223	In Stock
500MG	358	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Vandetanib
Note

Research use only, not for human use.
Brief Description

Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability.
Description

Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.
Synonyms

ZD6474
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR; VEGFR2; VEGFR3
Research Area

Cancer
Indication

Thyroid Cancer

Chemical Information

CAS Number

443913-73-3
Formula Weight

475.31
Molecular Formula

C22H24BrFN4O2
Purity

>98%(HPLC)
Solubility

DMSO: 4 mg/mL (8.41 mM)
SMILES

COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=C(F)C=C(Br)C=C3)C2=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Wedge SR, et al. Y Res. 2002, 62(16), 4645-4655.

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