Valbenazine( NBI-98854 )

Catalog No. M10117 CAS No. 1025504-45-3

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Product Name

Valbenazine
Note

Research use only, not for human use.
Brief Description

A novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor; is approved for the treatment of tardive dyskinesia.
Description

A novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor; is approved for the treatment of tardive dyskinesia.Other Indication Phase 3 Clinical(In Vitro):Valbenazine exhibits VMAT2 binding affinity in rat striatum and human platelets with Kis of 110 and 150 nM, respectively. (In Vivo):Valbenazine (10 mg/kg; orally) induces ptosis (primarily an adrenergic response) and increases plasma prolactin primarily a dopaminergic response.
In Vitro

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In Vivo

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Synonyms

NBI-98854
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Other Indications
Indication

Other Disease

CAS Number

1025504-45-3
Formula Weight

418.5695
Molecular Formula

C24H38N2O4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC
Chemical Name

L-Valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-yl ester

1. O'Brien CF, et al. Mov Disord. 2015 Oct;30(12):1681-7.

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