Vagistat ( (±)-Tioconazole )

Catalog No. M15506 CAS No. 65899-73-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Vagistat
Note

Research use only, not for human use.
Brief Description

Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast.
Description

Tioconazole is an antifungal medication of the Imidazole class used to treat infections caused by a fungus or yeast. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. In this way, tioconazole inhibits ergosterol synthesis, resulting in increased cellular permeability.
Synonyms

(±)-Tioconazole
Pathway

Microbiology/Virology
Target

Antifection
Recptor

14-α Demethylase
Research Area

Infection
Indication

——

CAS Number

65899-73-2
Formula Weight

387.71
Molecular Formula

C16H13Cl3N2OS
Purity

>98%(HPLC)
Solubility

Ethanol: 78 mg/mL (201.18 mM); DMSO: 78 mg/mL (201.18 mM)
SMILES

C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)OCC3=C(SC=C3)Cl
Chemical Name

1-(2-((2-chlorothiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

1.Ballard SA, et al. Biochem Pharmacol. 1988 Dec 15;37(24):4643-5

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