VXc-486
CAS No. 1384984-18-2
VXc-486 ( VXc486 )
Catalog No. M11600 CAS No. 1384984-18-2
VXc-486 (VXc486) is a novel inhibitor of gyrase B, potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 410 | Get Quote |
|
50MG | 1791 | Get Quote |
|
100MG | 2601 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameVXc-486
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NoteResearch use only, not for human use.
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Brief DescriptionVXc-486 (VXc486) is a novel inhibitor of gyrase B, potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis in vitro.
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DescriptionVXc-486 (VXc486) is a novel inhibitor of gyrase B, potently inhibits multiple drug-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis in vitro with MICs of 0.03-0.30 μg/ml and 0.08-5.48 μg/ml, respectively; VXc-486 is active against drug-resistant isolates, has bactericidal activity, and kills intracellular and dormant M. tuberculosis bacteria in a low-oxygen environment; inhibits the growth of multiple strains of Mycobacterium abscessus, Mycobacterium avium complex, and Mycobacterium kansasii (MICs=0.1-2.0 μg/ml), as well as several strains of Nocardia spp. (MICs=0.1-1.0 μg/ml); reduces mycobacterial burdens in lungs of infected mice in vivo, sterilizes M. tuberculosis infection when combined with rifapentine-pyrazinamide and bedaquiline-pyrazinamide.
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SynonymsVXc486
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1384984-18-2
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Formula Weight428.47
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Molecular FormulaC21H25FN6O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCCNC(=O)NC1=NC2=C(N1)C=C(C(=C2C3CCCO3)F)C4=CN=C(N=C4)C(C)(C)O
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Chemical NameN-Ethyl-N'-[6-fluoro-5-[2-(1-hydroxy-1-methylethyl)-5-pyrimidinyl]-7-[(2R)-tetrahydro-2-furanyl]-1H-benzimidazol-2-yl]urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Locher CP, et al. Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65.
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