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VU6012962
CAS No. 2313526-86-0
VU6012962( —— )
Catalog No. M24054 CAS No. 2313526-86-0
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 115 | In Stock |
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| 25MG | 224 | In Stock |
|
| 50MG | 403 | In Stock |
|
| 100MG | 592 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU6012962
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NoteResearch use only, not for human use.
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Brief DescriptionVU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
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DescriptionVU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
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In VitroVU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes.
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In VivoVU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice. Animal Model:C57Bl/6J male mice (8 weeks old)Dosage:1, 3, and 10 mg/kg Administration:I.p. injections; 60 minutes prior to testing Result:Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptormGlu7
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Research Area——
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Indication——
Chemical Information
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CAS Number2313526-86-0
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Formula Weight448.4
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Molecular FormulaC21H19F3N4O4
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (278.77 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
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SMILESCOC1=C(C=CC(=C1)C(=O)NC2=C(C=CC(=C2)OC(F)(F)F)N3C=NC=N3)OCC4CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Reed CW, et al. Discovery of an orally bioavailable and Central Nervous System (CNS) penetrant mGlu7 NegativeAllosteric Modulator (NAM) in vivo tool compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962). J Med Chem. 2019 Jan 4.
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