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VU6012962

CAS No. 2313526-86-0

VU6012962( —— )

Catalog No. M24054 CAS No. 2313526-86-0

VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 65 In Stock
10MG 115 In Stock
25MG 224 In Stock
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Biological Information

  • Product Name
    VU6012962
  • Note
    Research use only, not for human use.
  • Brief Description
    VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
  • Description
    VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
  • In Vitro
    VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes.
  • In Vivo
    VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice. Animal Model:C57Bl/6J male mice (8 weeks old)Dosage:1, 3, and 10 mg/kg Administration:I.p. injections; 60 minutes prior to testing Result:Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    mGlu7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2313526-86-0
  • Formula Weight
    448.4
  • Molecular Formula
    C21H19F3N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (278.77 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
  • SMILES
    COC1=C(C=CC(=C1)C(=O)NC2=C(C=CC(=C2)OC(F)(F)F)N3C=NC=N3)OCC4CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Reed CW, et al. Discovery of an orally bioavailable and Central Nervous System (CNS) penetrant mGlu7 NegativeAllosteric Modulator (NAM) in vivo tool compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962). J Med Chem. 2019 Jan 4.
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