VU0650786

Research use only, not for human use.

VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM).

VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.

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VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice.The pharmacokinetic parameters of VU0650786 (compound 106) in rats.

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Neuroscience

GluR

mGluR3

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1809085-30-0

387.8

C18H15ClFN5O2

>98% (HPLC)

DMSO: 240 mg/mL (618.88 mM; Need ultrasonic);H2O: insoluble

ClC1=CN=C(OCC2=NN([C@H](C)CN(C3=C(F)N=CC=C3)C4=O)C4=C2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years