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VU0650786
CAS No. 1809085-30-0
VU0650786( —— )
Catalog No. M23823 CAS No. 1809085-30-0
VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | In Stock |
|
| 10MG | 312 | In Stock |
|
| 25MG | 530 | In Stock |
|
| 50MG | 758 | In Stock |
|
| 100MG | 1044 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU0650786
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NoteResearch use only, not for human use.
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Brief DescriptionVU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM).
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DescriptionVU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.
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In Vitro——
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In VivoVU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice.The pharmacokinetic parameters of VU0650786 (compound 106) in rats.
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptormGluR3
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Research Area——
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Indication——
Chemical Information
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CAS Number1809085-30-0
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Formula Weight387.8
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Molecular FormulaC18H15ClFN5O2
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Purity>98% (HPLC)
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SolubilityDMSO: 240 mg/mL (618.88 mM; Need ultrasonic);H2O: insoluble
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SMILESClC1=CN=C(OCC2=NN([C@H](C)CN(C3=C(F)N=CC=C3)C4=O)C4=C2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500.
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