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VU0483605
CAS No. 1623101-11-0
VU0483605( —— )
Catalog No. M27457 CAS No. 1623101-11-0
VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | Get Quote |
|
| 5MG | 87 | Get Quote |
|
| 10MG | 147 | Get Quote |
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| 25MG | 290 | Get Quote |
|
| 50MG | 447 | Get Quote |
|
| 100MG | 672 | Get Quote |
|
| 200MG | 888 | Get Quote |
|
| 500MG | 1368 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVU0483605
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NoteResearch use only, not for human use.
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Brief DescriptionVU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.
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DescriptionVU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.(In Vitro):VU0483605 shows excellent mGlu1 PAM activity at both human and rat (pEC50 = 6.45 ± 0.11, 113 ± 5% Glu Max) and no activity as an mGlu4 PAM (EC50 >10 μM).
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In VitroVU0483605 proves superior with excellent mGlu1 PAM activity at both human (EC50 = 390 nM) and rat (EC50 = 356 nM, pEC50 = 6.45 ± 0.11, 113 ± 5% Glu Max) and no activity as an mGlu4 PAM (EC50 >10 μM).
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorTRPV1
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Research Area——
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Indication——
Chemical Information
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CAS Number1623101-11-0
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Formula Weight446.67
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Molecular FormulaC20H10Cl3N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (223.88 mM)
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SMILESO=C(NC1=CC=C(C(Cl)=C1)N2C(=O)C=3C=CC=C(Cl)C3C2=O)C4=NC=CC=C4Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jakab B, et al. Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat. Eur J Pharmacol. 2005 Jul 4;517(1-2):35-44.
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