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VU0071063
CAS No. 333415-38-6
VU0071063( VU-0071063 | VU 0071063 )
Catalog No. M24274 CAS No. 333415-38-6
VU0071063 is a Kir6.2/SUR1 activator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 72 | In Stock |
|
| 25MG | 147 | In Stock |
|
| 50MG | 222 | In Stock |
|
| 100MG | 332 | In Stock |
|
| 200MG | 494 | In Stock |
|
| 500MG | 782 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU0071063
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NoteResearch use only, not for human use.
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Brief DescriptionVU0071063 is a Kir6.2/SUR1 activator.
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DescriptionVU0071063 is a Kir6.2/SUR1 activator.
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In VitroVU0071063 (1 nM~1 mM; HEK-293 cells) dose dependently opens Kir6.2/SUR1. VU0071063 (0~20 μM; isolated cells) inhibits β-Cell excitability in mouse Islets. VU0071063 (10 μM; 1 hour; isolated cells) inhibits glucose-stimulated insulin secretion.VU0071063 dose dependently and reversibly hyperpolarizes the β-cell membrane potential, which, in turn, inhibits glucose-stimulated Ca2+ entry and insulin secretion. The actions of VU0071063 on the β-cell membrane potential are reversed by tolbutamide, and glucose stimulated insulin secretion is unaffected by the inactive analog 34MT, indicating that the effects are mediated through Kir6.2/SUR1.
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In VivoVU0071063 (50 mg/kg; i.p.; 4 hours) leads to a significant increase in blood glucose at 60 minutes. Animal Model:Male C57BL/6 mice (10-12 weeks age)Dosage:50 mg/kg (Pharmacokinetic analysis)Administration: I.p.Result:Led to a significant increase in blood glucose at 60 minutes.
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SynonymsVU-0071063 | VU 0071063
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorKir6.2/SUR1
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Research Area——
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Indication——
Chemical Information
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CAS Number333415-38-6
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Formula Weight326.4
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Molecular FormulaC18H22N4O2
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESO=C(N1C)N(C)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol Pharmacol. 2014 Jun;85(6):858-65. doi: 10.1124/mol.114.091884. Epub 2014 Mar 19.
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