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VTP50469

CAS No. 2169916-18-9

VTP50469( —— )

Catalog No. M23981 CAS No. 2169916-18-9

VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VTP50469
  • Note
    Research use only, not for human use.
  • Brief Description
    VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
  • Description
    VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Unconditioned immunodeficient (NSG) mice with MV4;11 cells Dosage:15 mg/kg, 30 mg/kg, and 60 mg/kg Administration:Oral administration; twice a day; for 28 days Result:Was highly efficacious across all dosage levels and all treatment groups had a significant survival advantage over the control group.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|Menin-MLL interaction
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2169916-18-9
  • Formula Weight
    630.82
  • Molecular Formula
    C32H47FN6O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (198.15 mM; Need ultrasonic)
  • SMILES
    CC(C)N(C(C)C)C(=O)C1=C(C=CC(=C1)F)OC2=CN=CN=C2N3CC4(C3)CCN(CC4)CC5CCC(CC5)NS(=O)(=O)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Krivtsov AV, et al. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019 Dec 9;36(6):660-673.e11.
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