
STAT3-IN-11
CAS No. 2503096-50-0
STAT3-IN-11( —— )
Catalog No. M35503 CAS No. 2503096-50-0
STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.
Purity : >98% (HPLC)






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Biological Information
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Product NameSTAT3-IN-11
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NoteResearch use only, not for human use.
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Brief DescriptionSTAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.
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DescriptionSTAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers.
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In VitroSTAT3-IN-11 (20 μM, 48 h) has 97.86% inhibitory effect on MDA-MB-231 cells.STAT3-IN-11 (0-30 μM, 48 h) inhibits several cancer cells with IC50 values of 6.01 μM (MDA-MB-231), 7.02μM (HepG2, A549), and normal human cells with IC50 values of 26.54 μM (MDA-MB-10A), 26.69 μM (PBMCs), 12.52 μM (HFL-1) .STAT3-IN-11 (2.5-10 μM, 6 h) inhibits the phosphorylation of STAT3 (stimulated by IL-6 in MDA-MB-231) at site pTyr705 in a dose-dependent manner.STAT3-IN-11 (2.5-10 μM, 6 h) inhibits the expression of the downstream gene (Survivin and Mcl-1) of STAT3 in a concentration-dependent manner.STAT3-IN-11 (2.5-10 μM, 6 h) has no effects on the typical upstream kinases of STAT3 such as p-JAK2 and p-Src and the phosphorylation of STAT1 (a STAT isoform) .STAT3-IN-11 (2.5-10 μM, 48 h) can induce cell apoptosis in a dose-manner.Cell Cytotoxicity Assay Cell Line:MDA-MB-231 cells Concentration:20 μM Incubation Time:48 hours Result:The antiproliferative activity reached 97.86%.Cell Cytotoxicity Assay Cell Line:MDA-MB231, A549, MDA-MB-10A, PBMCs and HFL-1 cells Concentration:20 μM Incubation Time:48 hours Result:Inhibited with IC50 values of 6.01, 7.20, 7.02, 26.54, 25.69 and 12.52 μM for MDA-MB231, A549, MDA-MB-10A, PBMCs and HFL-1 cells, respectively.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:2.5,5 and 10 μM Incubation Time:6 hours Result:Decrease the level of p-STAT3 at site pTyr705 in a concentration dependent manner.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:2.5,5 and 10 μM Incubation Time:6 hours Result:Down-regulated the level of STAT3 downstream genes.Apoptosis Analysis Cell Line:MDA-MB-231 cells Concentration:5, 10 and 15 μM Incubation Time:48 hours Result:The percentage of apoptotic cells was 24.4% at a concentration of 15 μM.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | STAT
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Research Area——
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Indication——
Chemical Information
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CAS Number2503096-50-0
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Formula Weight335.35
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Molecular FormulaC20H17NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (298.20 mM; Ultrasonic )
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SMILESCC1=C(CCNC(=O)c2ccccc2)C(=O)c2c(O)cccc2C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li N, et al. Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition. Bioorg Chem. 2020 Nov;104:104208. ?
molnova catalog



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