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VT-1598
CAS No. 2089320-99-8
VT-1598 ( VT1598 )
Catalog No. M13269 CAS No. 2089320-99-8
VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 284 | Get Quote |
|
| 50MG | 1485 | Get Quote |
|
| 100MG | 2385 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVT-1598
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NoteResearch use only, not for human use.
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Brief DescriptionVT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM.
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DescriptionVT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM; is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4; exhibits excellent potency against yeast, dermatophyte, and mold fungal pathogens.
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SynonymsVT1598
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PathwayMicrobiology/Virology
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TargetFungal
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RecptorFungal
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number2089320-99-8
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Formula Weight584.54
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Molecular FormulaC31H20F4N6O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC(=CC=C1COC2=CC=C(C=C2)C#CC3=CN=C(C=C3)C(C(CN4C=NN=N4)(C5=C(C=C(C=C5)F)F)O)(F)F)C#N
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Chemical Name(R)-4-((4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)ethynyl)phenoxy)methyl)benzonitrile
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hargrove TY, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00570-17.
2. Yates CM, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248.
3. Wiederhold NP, et al. J Antimicrob Chemother. 2018 Feb 1;73(2):404-408.
2. Yates CM, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248.
3. Wiederhold NP, et al. J Antimicrob Chemother. 2018 Feb 1;73(2):404-408.
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