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Home - Products - JAK/STAT Signaling - Pim - VS-II-173

VS-II-173

CAS No. 1627962-21-3

VS-II-173( —— )

Catalog No. M12421 CAS No. 1627962-21-3

VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VS-II-173
  • Note
    Research use only, not for human use.
  • Brief Description
    VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively.
  • Description
    VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell); acts synergistically with the anthracycline daunorubicin, and additively with a number of other anti-cancer drugs; attenuates phosphorylation of Pim kinase substrates, shows towards cell lines harboring the FLT3-ITD mutation (Molm-13, FLT3-ITD heterozygous and MV4-11 FLT3-ITD homozygous) with EC50 of 2-3 uM; also induces cell death also in AML patient blasts, including blast carrying high-risk FLT3-ITD mutation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    Pim
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1627962-21-3
  • Formula Weight
    264.244
  • Molecular Formula
    C14H8N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    5-nitro-3H-pyrazolo[4,3-a]phenanthridine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Suchaud V, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4704-10. 2. Bj?rnstad R, et al. Mol Cancer Ther. 2019 Jan 24. pii: molcanther.1234.2017. doi: 10.1158/1535-7163.MCT-17-1234.
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