
VS-II-173
CAS No. 1627962-21-3
VS-II-173( —— )
Catalog No. M12421 CAS No. 1627962-21-3
VS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
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50MG | 1782 | Get Quote |
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100MG | 2250 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameVS-II-173
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NoteResearch use only, not for human use.
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Brief DescriptionVS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively.
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DescriptionVS-II-173 is a highly potent Pim1 and Pim3 inhibitor with IC50 of 70 and 20 nM respectively, and a potent and selective inducer of AML cell death (IC50=5.5 uM, Molm-13 cell); acts synergistically with the anthracycline daunorubicin, and additively with a number of other anti-cancer drugs; attenuates phosphorylation of Pim kinase substrates, shows towards cell lines harboring the FLT3-ITD mutation (Molm-13, FLT3-ITD heterozygous and MV4-11 FLT3-ITD homozygous) with EC50 of 2-3 uM; also induces cell death also in AML patient blasts, including blast carrying high-risk FLT3-ITD mutation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayJAK/STAT Signaling
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TargetPim
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RecptorPim
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Research Area——
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Indication——
Chemical Information
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CAS Number1627962-21-3
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Formula Weight264.244
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Molecular FormulaC14H8N4O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-nitro-3H-pyrazolo[4,3-a]phenanthridine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Suchaud V, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4704-10.
2. Bj?rnstad R, et al. Mol Cancer Ther. 2019 Jan 24. pii: molcanther.1234.2017. doi: 10.1158/1535-7163.MCT-17-1234.
molnova catalog



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